ABSTRACT
BACKGROUND: Thrombocytopenia refers to a reduction in platelet count below 1.5 lakh/microliter. The presence of thrombocytopenia in a hemogram should alert the physician to identify the underlying etiology for the prompt management of the patient. Timely identification and treatment prevent bleeding manifestations, requirement of platelet transfusions/steroids and overall impact on mortality of the patients. AIM OFSTUDY:Analysis to study the etiology, bleeding manifestation, percentage of patients requiring platelet transfusion, length of hospital stay in patients with thrombocytopenia. METHODOLOGY: 100 cases thrombocytopenia both male and female were included in the study. The diagnosis was made on peripheral smear and Hemogram. RESULTS: Dengue fever was the most common cause of thrombocytopenia with 43 cases. Sepsis with 23 cases was the second commonest. Bleeding manifestations were seen in 23% of the study population.100% of the patients with platelet count less than 10,000/microlitre had bleeding manifestations. 26 patients (26%) received platelet transfusion out of which 23 were therapeutic and 3 were prophylactic transfusions. Steroid therapy was given in 11% of patients. Mortality was highest in patients with sepsis induced thrombocytopenia. CONCLUSION:This study shows that Dengue fever is the commonest diagnosis made in patients who are detected to have thrombocytopenia. One fifth of patients with platelet count less than 1,00,000/microlitre tend to have bleeding manifestation, commonest being GI bleed, petechial rash and epistaxis. Majority of the bleeding occurs with platelet count less than 10,000. The proportion of patients receiving therapeutic platelet transfusion was higher compared to prophylactic transfusion.
ABSTRACT
Background: In India, in the last one and half decades longevity of the people has increased due to decline in mortality rate, better medical and health care facilities and improvements in overall quality of life of people. Presently India has the second largest geriatric population in the globe. In 2001, geriatric population was 77 million in India and it is estimated that in India total number of elderly will rise to 150 million by 2025 and by the year 2050 the number would rise to about 324 million.4 Methods: A community based cross sectional study was conducted in an urban slum located in Secunderabad. Almost 225 subjects more than 60 years were included in study after giving oral consent. People with severe morbidity and unable to give consent were excluded from study. Results: Majority (70%) of the resident experienced verbal abuse followed by physical abuse (13%) at least one time. About 11% felt they were being neglected by their family members. Daughter-in-law was the major person involved in the elder abuse accounting for 45.9%, followed by son 24.3%. Abuse from relatives accounted for 21.6%. Spouse and daughter were involved in elder abuse in about 5.4% and 2.7% cases respectively. Conclusions: As recently said by Financial Minister in Parliament of India, old age population growing drastically in India, especially in south India. Increasing geriatric population leading to increase in need of health care and psychological assistance.
ABSTRACT
BACKGROUND: Atrial fiillation (AF) is the most common cardiac arrhythmia, occurring in 1–2% of the general population. AF confers a 5–fold risk of stroke. Much earlier detection of the arrhythmia might allow the timely introduction of therapies to protect the patient, not only from the consequences of the arrhythmia, but also from progression of AF from an easily treated condition to an utterly refractory problem. AIM OF STUDY: Analysis of etiological features, clinical features and Complications of atrial fiillation. METHODOLOGY: 100 cases of atrial fiillation both male and female were included in the study. The diagnosis was made on clinical grounds and then confirmed by ECG and Echo cardiogram. RESULTS: In this study of atrial fiillation, the occurrence of AF is maximum in age group 61 and above. Out of 100 cases 43 cases were male, 57 cases were female, and 60 cases were rheumatic heart disease. CONCLUSION: In this study common aetiology of AF was RHD 60% followed by Hypertensive heart disease and Ischemic heart disease each carries 10%. The most common symptomatic presentations were dyspnea and palpitation followed by chest pain and dizziness. The commonest complication noted was heart failure.
ABSTRACT
Role of peripheral and central noradrenaline and 5-hydroxytryptamine in the carrageenin-induced pedal oedema in rats was studied using agents which influence catecholamine synthesis and receptor activity of noradrenaline and 5-hydroxytryptamine. Reserpine, guanethidine, α-methyl-p-tyrosine, diethyldithiocarbamate, 6-hydroxydopamine, phenoxybenzamine, phentolamine, chlorpromazine and yohimbine markedly inhibited carrageenin-induced pedal oedema. However, 6-hydroxydopamine given intracerebroventricularly, 5,6-dihydroxytryptamine, p-chlorophenylalanine, lower dose of yohimbine, pro pranolol, haloperidol, cyproheptadine and mepyramine did not alter the carrageenin-induced oedema, whereas, cyproheptadine and mepyramine given simultaneously, markedly inhibited carrageenin-induced oedema. Our studies indicate that the process of oedema formation in rats by carrageenin involves both the peripheral noradrenaline and 5-hydroxytryptamine.